4-Hydroxynonenal-d3

4-Hydroxynonenal-d3 is the deuterium labeled 4-Hydroxynonenal. 4-Hydroxynonenal (4-HNE) is an α, β unsaturated hydroxyalkenal and an oxidative/nitrosative stress biomarker. 4-Hydroxynonenal is a substrate and an inhibitor of acetaldehyde dehydrogenase 2 (ALDH2) . 4-Hydroxynonenal can modulate a number of signaling processes mainly through forming covalent adducts with nucleophilic functional groups in proteins, nucleic acids, and membrane lipids. 4-Hydroxynonenal plays an important role in cancer through mitochondria[1][2][3].

Product Specifications

CAS Number

[148706-06-3]

Product Name Alternative

4-HNE-d3

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Aldehyde Dehydrogenase (ALDH) ; Endogenous Metabolite; Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

Metabolic Enzyme/Protease; Others

Field of Research

Cancer; Neurological Disease; Cardiovascular Disease

Concentration

3.14 mM * 100 μL in Methyl acetate

Purity

99.0

Solubility

10 mM in DMSO

Smiles

O=C/C=C/C(O)CCCCC([2H])([2H])[2H]

Molecular Formula

C9H13D3O2

Molecular Weight

159.24

Precautions

H302, H315, H319, H335

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Zhong H, et al. Role of lipid peroxidation derived 4-hydroxynonenal (4-HNE) in cancer: focusing on mitochondria. Redox Biol. 2015;4:193-9.|[3]Csala M, et al. On the role of 4-hydroxynonenal in health and disease. Biochim Biophys Acta. 2015 May;1852 (5) :826-38.|[4]Bhowmick S, et al. Traumatic brain injury-induced downregulation of Nrf2 activates inflammatory response and apoptotic cell death. J Mol Med (Berl) . 2019 Nov 22.