Leukotriene D4-d5
Leukotriene D4-d5 is the deuterium labeled Leukotriene D4. Leukotriene D4 is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) produced by the metabolism of LTC4 by γ-glutamyl transpeptidase. Leukotriene D4 is the first cysteinyl-leukotriene metabolite of LTC4. Leukotriene D4-induced bronchoconstriction and enhanced vascular permeability contribute to the pathogenesis of asthma and acute hypersensitivity.
Product Specifications
CAS Number
1240398-17-7
UNSPSC
12352211
Target
Drug Metabolite; Endogenous Metabolite; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Metabolic Enzyme/Protease; Others
Field of Research
Inflammation/Immunology; Cardiovascular Disease
Concentration
199.33 μM * 250 μL in Ethanol
Purity
98.4
Solubility
10 mM in DMSO
Smiles
N[C@@H](CS[C@H](/C=C/C=C/C=C\C/C=C\CCCC([2H])(C([2H])([2H])[2H])[2H])[C@H](CCCC(O)=O)O)C(NCC(O)=O)=O
Molecular Formula
C25H35D5N2O6S
Molecular Weight
501.69
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.
Shipping Conditions
Blue Ice
Storage Conditions
Solution, -20°C, 2 years
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Frequently Asked Questions
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