9S-HODE

9S-HODE (Alpha-dimorphecolic acid) is an octadecadienoic acid and the main active derivative of linoleic acid, which can reduce the viability of HL-60 cells and induce apoptosis. 9S-HODE is rich in lipid peroxidation (LPO) products and is almost an ideal marker for LPO[1][2].

Product Specifications

CAS Number

73543-67-6

Product Name Alternative

Alpha-dimorphecolic acid

UNSPSC

12352211

Hazard Statement

H225, H319

Target

Apoptosis; Endogenous Metabolite

Type

Reference compound

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/9s-hode.html

Concentration

5.31 mM * 63.5 μL in Ethanol

Purity

98.0

Solubility

10 mM in DMSO

Smiles

CCCCC/C=C\C=C\[C@@H](O)CCCCCCCC(O)=O

Molecular Formula

C18H32O3

Molecular Weight

296.44

Precautions

H225, H319

References & Citations

[1]Liu S, et al. Linoleic acid derivatives target miR-361-3p/BTG2 to confer anticancer effects in acute myeloid leukemia. J Biochem Mol Toxicol. 2023 Nov;37 (11) :e23481.|[2]Spiteller P, et al. 9-Hydroxy-10, 12-octadecadienoic acid (9-HODE) and 13-hydroxy-9, 11-octadecadienoic acid (13-HODE) : excellent markers for lipid peroxidation[J]. Chemistry and Physics of Lipids, 1997, 89 (2) : 131-139.