Leukotriene C4

Leukotriene C4 is a eicosanoid lipid mediator and produced by immune cells during type 2 inflammation. Leukotriene C4 can mediate inflammation, allergy, bronchoconstriction, and vascular leakage[1][2].

Product Specifications

CAS Number

[72025-60-6]

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Endogenous Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/leukotriene-c4.html

Concentration

159.8 μM * 250 μL in Ethanol

Purity

97.0

Solubility

10 mM in DMSO

Smiles

OC(CCC[C@H](O)[C@@H](/C=C/C=C/C=C\C/C=C\CCCCC)SC[C@@H](C(NCC(O)=O)=O)NC(CC[C@H](N)C(O)=O)=O)=O

Molecular Formula

C30H47N3O9S

Molecular Weight

625.77

Precautions

H302, H315, H319, H335

References & Citations

[1]Voisin T, et, al. The CysLT2R receptor mediates leukotriene C4-driven acute and chronic itch. Proc Natl Acad Sci U S A. 2021 Mar 30;118 (13) :e2022087118. |[2]Dvash E, et, al. Leukotriene C4 is the major trigger of stress-induced oxidative DNA damage. Nat Commun. 2015 Dec 11;6:10112.