5-HETE
5-HETE ((±) -5-HETE), a fatty acid, is a oxidative derivative of Arachidonic acid. 5-HETE is a mixture of 5 (S) -HETE and 5 (R) -HETE. 5-HETE is a potent aggregating agent that induces the aggregation of neutrophils with an IC50 value of 200 nM[1].
Product Specifications
CAS Number
[71030-39-2]
Product Name Alternative
(±) -5-HETE
UNSPSC
12352211
Target
Endogenous Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/5-hete.html
Concentration
312.04 μM * 1 mL in Ethanol
Purity
96.8
Solubility
10 mM in DMSO
Smiles
CCCCC/C=C\C/C=C\C/C=C\C=C\C(O)CCCC(O)=O
Molecular Formula
C20H32O3
Molecular Weight
320.47
References & Citations
[1]J T O'Flaherty, et al. Neutrophil-aggregating activity of monohydroxyeicosatetraenoic acids. Am J Pathol. 1981 Jul;104 (1) :55-62.
Shipping Conditions
Blue Ice
Storage Conditions
Solution, -20°C, 2 years
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
Hypoxia Inducible Factor 2a (Hypoxia Inducible Factor 2 alpha, HIF-2a, Endothelial PAS Domain Containing Protein 1, EPAS1, EPAS-1, HIF-2 alpha, HIF2a, HIF1 alpha-like Factor, HLF, Member of PAS Protein 2, MOP2, PASD2)
Lentiviral mouse Mef2d shRNA (UAS) - Lentiviral mouse Mef2d shRNA (UAS, iRFP) (25)