Dehydroepiandrosterone sulfate-d6 (sodium dihydrate)

Dehydroepiandrosterone sulfate sodium dihydrate-d6 sodium dihydrate is the deuterium labeled Dehydroepiandrosterone sulfate sodium dihydrate. Dehydroepiandrosterone sulfate (DHEA sulfate; Prasterone sulfate) sodium dihydrate is a neurosteroid and the main secretion product of the adrenal gland. Dehydroepiandrosterone sulfate sodium dihydrate has both non-competitive antagonist activity of GABAA receptor and agonist activity of σ1 receptor. Dehydroepiandrosterone sulfate sodium dihydrate can partially penetrate the blood-brain barrier, inhibit GABAA receptor-mediated chloride influx, enhance NMDA receptor activity through σ1 receptors, exert anti-inflammatory, anti-glucocorticoid and antidepressant effects, and increase convulsive sensitivity. Dehydroepiandrosterone sulfate sodium dihydrate participates in neuroprotection, neurite growth regulation and catecholamine secretion regulation, and can be used in the study of depression, post-traumatic stress disorder (PTSD), Alzheimer's disease, etc. Dehydroepiandrosterone sulfate sodium dihydrate may also be a biomarker for cardiovascular disease mortality, and its concentration is independently and negatively correlated with mortality[1][2][3][4][5].

Product Specifications

Product Name Alternative

DHEA sulfate-d6 (sodium dihydrate) ; Prasterone sulfate-d6 (sodium dihydrate)

UNSPSC

12352100

Target

GABA Receptor; iGluR; Isotope-Labeled Compounds; NF-κB; PPAR; Sigma Receptor

Type

Isotope-Labeled Compounds

Related Pathways

Cell Cycle/DNA Damage; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB; Others; Vitamin D Related/Nuclear Receptor

Field of Research

Metabolic Disease; Inflammation/Immunology; Neurological Disease

Purity

98.00

Solubility

10 mM in DMSO

Smiles

C[C@@]12[C@]3([H])[C@](CC([2H])=C1C([2H])([2H])[C@@](C([2H])([2H])C2)([2H])OS(=O)(O[Na])=O)([H])[C@@]4([H])[C@](CC3)(C(CC4)=O)C.O.O

Molecular Formula

C19H25D6NaO7S

Molecular Weight

432.54

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Baulieu EE, et al. Dehydroepiandrosterone (DHEA), DHEA sulfate, and aging: contribution of the DHEAge Study to a sociobiomedical issue. Proc Natl Acad Sci U S A. 2000 Apr 11;97 (8) :4279-84.|[3]Maninger N, et al. Neurobiological and neuropsychiatric effects of dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS) . Front Neuroendocrinol. 2009 Jan;30 (1) :65-91.|[4]Dillon JS. Dehydroepiandrosterone, dehydroepiandrosterone sulfate and related steroids: their role in inflammatory, allergic and immunological disorders. Curr Drug Targets Inflamm Allergy. 2005 Jun;4 (3) :377-85.|[5]Barrett-Connor E, et al. A prospective study of dehydroepiandrosterone sulfate, mortality, and cardiovascular disease. N Engl J Med. 1986 Dec 11;315 (24) :1519-24.