Prostaglandin J2

Prostaglandin J2 (PGJ2), an endogenous metabolite of Prostaglandin D2 (PGD2; HY-101988), is a potent PGD2 receptor (DP) agonist with Kis of 0.9 nM and 6.6 nM for hDP and hCRTH2, respectively. Prostaglandin J2 stimulates intracellular cyclic AMP production with an EC50 value of 1.2 nM. Prostaglandin J2 induces oxidative stress and neuronal apoptosis. Prostaglandin J2 induces the accumulation/aggregation of ubiquitinated (Ub) proteins. Prostaglandin J2 is highly neurotoxic and potentially contributes to many neurodegenerative conditions, including Alzheimer's (AD) and Parkinson's diseases (PD) [1][2][3][4].

Product Specifications

CAS Number

[60203-57-8]

Product Name Alternative

PGJ2

UNSPSC

12352211

Hazard Statement

H225, H319, H336

Target

Endogenous Metabolite; Prostaglandin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Metabolic Enzyme/Protease

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/prostaglandin-j2.html

Concentration

14.95 mM * 100 μL in Methyl acetate

Purity

98.10

Smiles

CCCCC[C@H](O)/C=C/[C@@H]1[C@H](C=CC1=O)C/C=C\CCCC(O)=O

Molecular Formula

C20H30O4

Molecular Weight

334.45

Precautions

H225, H319, H336

References & Citations

[1]D H Wright, et al. Characterization of the recombinant human prostanoid DP receptor and identification of L-644,698, a novel selective DP agonist. Br J Pharmacol. 1998 Apr;123 (7) :1317-24.|[2]Nicole Sawyer, et al. Molecular pharmacology of the human prostaglandin D2 receptor, CRTH2. Br J Pharmacol. 2002 Dec;137 (8) :1163-72.|[3]Maria E Figueiredo-Pereira, et al. Prostaglandin J2: a potential target for halting inflammation-induced neurodegeneration. Ann N Y Acad Sci. 2016 Jan;1363 (1) :125-37.|[4]Chuhyon Corwin, et al. Prostaglandin D2/J2 signaling pathway in a rat model of neuroinflammation displaying progressive parkinsonian-like pathology: potential novel therapeutic targets. J Neuroinflammation. 2018 Sep 20;15 (1) :272.