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Zymostenol

Product Specifications

UNSPSC Description

Zymostenol (5a-Cholest-8-en-3b-ol) is a late-stage precursor in the biosynthesis of cholesterol. Zymostenol is a RORγ agonist (EC50: 1 μM)[1][2][3].

Target Antigen

Endogenous Metabolite; ROR

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/zymostenol.html

Purity

99.33

Solubility

DMF : 3 mg/mL (ultrasonic;warming)

Smiles

CC(C)CCC[C@@H](C)[C@H]1CC[C@@]2([H])C(CC[C@@]3([H])C[C@@H](O)CC[C@]43C)=C4CC[C@]12C

Molecular Weight

386.65

References & Citations

[1]Hu X, et al. Sterol metabolism controls T(H)17 differentiation by generating endogenous RORγ agonists. Nat Chem Biol. 2015 Feb;11(2):141-7. |[2]Hubler Z, et al. Accumulation of 8,9-unsaturated sterols drives oligodendrocyte formation and remyelination. Nature. 2018 Aug;560(7718):372-376. |[3]Payré B, et al. Microsomal antiestrogen-binding site ligands induce growth control and differentiation of human breast cancer cells through the modulation of cholesterol metabolism. Mol Cancer Ther. 2008 Dec;7(12):3707-18.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-113345/Zymostenol-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-113345/Zymostenol-SDS-MedChemExpress.pdf

Clinical Information

No Development Reported

CAS Number

566-97-2

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