Zymostenol

Zymostenol (5a-Cholest-8-en-3b-ol) is a late-stage precursor in the biosynthesis of cholesterol. Zymostenol is a RORγ agonist (EC50: 1 μM) [1][2][3].

Product Specifications

CAS Number

[566-97-2]

Product Name Alternative

5a-Cholest-8-en-3b-ol

UNSPSC

12352211

Target

Endogenous Metabolite; ROR

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/zymostenol.html

Purity

99.33

Solubility

DMF : 3 mg/mL (ultrasonic; warming)

Smiles

CC(C)CCC[C@@H](C)[C@H]1CC[C@@]2([H])C(CC[C@@]3([H])C[C@@H](O)CC[C@]43C)=C4CC[C@]12C

Molecular Formula

C27H46O

Molecular Weight

386.65

References & Citations

[1]Hu X, et al. Sterol metabolism controls T (H) 17 differentiation by generating endogenous RORγ agonists. Nat Chem Biol. 2015 Feb;11 (2) :141-7. |[2]Hubler Z, et al. Accumulation of 8,9-unsaturated sterols drives oligodendrocyte formation and remyelination. Nature. 2018 Aug;560 (7718) :372-376. |[3]Payré B, et al. Microsomal antiestrogen-binding site ligands induce growth control and differentiation of human breast cancer cells through the modulation of cholesterol metabolism. Mol Cancer Ther. 2008 Dec;7 (12) :3707-18.