12S-HHT
12S-HHT (12 (S) -HHTrE) is an enzymatic product of prostaglandin H2 (PGH2) derived from cyclooxygenase (COX) -mediated arachidonic acid metabolism. 12S-HHT is an endogenous ligand for BLT2 that fully activates BLT2 in vivo. 12S-HHT suppresses UV-induced IL-6 synthesis in keratinocytes, exerting an anti-inflammatory activity[1][2].
Product Specifications
CAS Number
54397-84-1
Product Name Alternative
12 (S) -HHTrE
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
Endogenous Metabolite; Leukotriene Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/12s-hht.html
Concentration
356.6 μM * 250 μL in Ethanol
Purity
99.0
Solubility
10 mM in DMSO
Smiles
CCCCC[C@H](O)/C=C/C=C/C/C=C\CCCC(O)=O
Molecular Formula
C17H28O3
Molecular Weight
280.40
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
Solution, -20°C, 2 years
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Human Endogenous Metabolite; LTB4
Frequently Asked Questions
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