12S-HHT

12S-HHT (12 (S) -HHTrE) is an enzymatic product of prostaglandin H2 (PGH2) derived from cyclooxygenase (COX) -mediated arachidonic acid metabolism. 12S-HHT is an endogenous ligand for BLT2 that fully activates BLT2 in vivo. 12S-HHT suppresses UV-induced IL-6 synthesis in keratinocytes, exerting an anti-inflammatory activity[1][2].

Product Specifications

CAS Number

[54397-84-1]

Product Name Alternative

12 (S) -HHTrE

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Endogenous Metabolite; Leukotriene Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/12s-hht.html

Concentration

356.6 μM * 250 μL in Ethanol

Purity

99.0

Solubility

10 mM in DMSO

Smiles

CCCCC[C@H](O)/C=C/C=C/C/C=C\CCCC(O)=O

Molecular Formula

C17H28O3

Molecular Weight

280.40

Precautions

H302, H315, H319, H335

References & Citations

[1]Saeki K, et al. Identification, signaling, and functions of LTB4 receptors. Semin Immunol. 2017;33:30-36.|[2]Lee JW, et al. 12 (S) -Hydroxyheptadeca-5Z,8E,10E-trienoic acid suppresses UV-induced IL-6 synthesis in keratinocytes, exerting an anti-inflammatory activity. Exp Mol Med. 2012;44 (6) :378-386.|[3]Okuno T, et al. Metabolism and biological functions of 12 (S) -hydroxyheptadeca-5Z,8E,10E-trienoic acid. Prostaglandins Other Lipid Mediat. 2021;152:106502.