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Etiocholanolone-d5

Etiocholanolone-d5 is the deuterium labeled Etiocholanolone. Etiocholanolone (5β-Androsterone) is the excreted metabolite of testosterone and has anticonvulsant activity[1]. Etiocholanolone is a less potent?neurosteroid positive allosteric modulator? (PAM) of the GABAA?receptor than its?enantiomer form[2].

Product Specifications

CAS Number

1620102-33-1

Product Name Alternative

5β-Androsterone-d5

UNSPSC

12352211

Target

Endogenous Metabolite; GABA Receptor; Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; Others

Field of Research

Neurological Disease

Purity

99.20

Solubility

DMSO : 50 mg/mL (ultrasonic; warming)

Smiles

C[C@@]12[C@]3([H])[C@](CC[C@]1([H])C([2H])([2H])[C@](C([2H])([2H])C2)([2H])O)([H])[C@@]4([H])[C@](CC3)(C(CC4)=O)C

Molecular Formula

C19H25D5O2

Molecular Weight

295.47

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Ping Li, et al. Natural and Enantiomeric Etiocholanolone Interact With Distinct Sites on the Rat alpha1beta2gamma2L GABAA Receptor. Mol Pharmacol. 2007 Jun;71 (6) :1582-90.|[3]Dorota Zolkowska, et al. Anticonvulsant Potencies of the Enantiomers of the Neurosteroids Androsterone and Etiocholanolone Exceed Those of the Natural Forms. Psychopharmacology (Berl) . 2014 Sep;231 (17) :3325-32.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Isotope-Labeled Compounds

Clinical Information

No Development Reported

Frequently Asked Questions

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