Lithocholic acid 3-sulfate (disodium)

Lithocholic acid 3-sulfate disodium is a GPR39 agonist with EC50s of 41 and 42.4 (absence of Zn2+) and 0.88 and 0.97 μM (presence of Zn2+) in M39-20 and hGPR39-2 cells, respectively. Lithocholic acid 3-sulfate disodium stimulates GPR39 receptors to initiate intracellular calcium signaling, independent of Zn2+ binding sites H17 and H19. Lithocholic acid 3-sulfate disodium can be used for the research of gallbladder disease[1].

Product Specifications

CAS Number

[64936-81-8]

Product Name Alternative

Sulfolithocholic acid (disodium) ; LCAS (disodium)

UNSPSC

12352200

Hazard Statement

H302, H315, H319, H335

Target

GPR39

Type

Biochemical Assay Reagents

Related Pathways

GPCR/G Protein

Field of Research

Inflammation/Immunology; Others

Assay Protocol

https://www.medchemexpress.com/lithocholic-acid-3-sulfate-disodium.html

Purity

99.93

Solubility

DMSO : 10 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 25 mg/mL (ultrasonic)

Smiles

C[C@]1(CC2)[C@](CC[C@]1([H])[C@H](C)CCC(O[Na])=O)([H])[C@@](CC[C@]3([H])C[C@@H]4O[S](=O)(O[Na])=O)([H])[C@@]2([H])[C@]3(CC4)C

Molecular Formula

C24H38Na2O6S

Molecular Weight

500.60

Precautions

H302, H315, H319, H335

References & Citations

[1]Zi, Zhentao; Xian, Yi; Han, Shangchen; Zhou, Enxing; Wang, Meihuang; Rao, Yi. Use of bile acids and derivatives thereof in preparation of GPR39 agonist. WO2021083336A1.