Guanosine triphosphate-13C10 (dilithium)

Guanosine triphosphate-13C10 (GTP-13C10) dilithium is 13C-labeled Guanosine triphosphate (HY-113225) . Guanosine triphosphate is a native nucleotide. The derivatives of GTP may be used as specific inhibitors against COVID-19.

Product Specifications

Product Name Alternative

GTP-13C10 (dilithium)

UNSPSC

12352005

Target

DNA/RNA Synthesis; Endogenous Metabolite; Isotope-Labeled Compounds; Nucleoside Antimetabolite/Analog; SARS-CoV

Type

Isotope-Labeled Compounds

Related Pathways

Anti-infection; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Others

Applications

COVID-19-anti-virus

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/guanosine-triphosphate-13c10-dilithium.html

Concentration

100 mM in 18.35 μL Tris HCl/H2O buffer pH=7.5

Purity

99.4

Solubility

10 mM in DMSO

Smiles

O=P(O)(O[Li])OP(OP(O[13CH2][13C@H]1O[13C@@H](N2[13C](N=[13C](N)N[13C]3=O)=[13C]3N=[13CH]2)[13C@H](O)[13C@@H]1O)(O)=O)(O[Li])=O

Molecular Formula

13C10H14Li2N5O14P3

Molecular Weight

544.97

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Abdo A Elfiky, et al. Anti-HCV, nucleotide inhibitors, repurposing against COVID-19. Life Sci. 2020 May 1;248:117477.