Guanosine triphosphate-15N5, d14 (dilithium)

Guanosine triphosphate-15N5, d14 (GTP-15N5, d14) dilithium is deuterium and 15N labeled Guanosine triphosphate (HY-113225) . Guanosine triphosphate is a native nucleotide. The derivatives of GTP may be used as specific inhibitors against COVID-19.

Product Specifications

Product Name Alternative

GTP-15N5, d14 (dilithium)

UNSPSC

12352005

Target

DNA/RNA Synthesis; Endogenous Metabolite; Isotope-Labeled Compounds; Nucleoside Antimetabolite/Analog; SARS-CoV

Type

Isotope-Labeled Compounds

Related Pathways

Anti-infection; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Others

Applications

COVID-19-anti-virus

Field of Research

Cancer; Infection

Concentration

100 mM in 18.05 μL Tris HCl/D2O buffer pH=7.5

Purity

98.4

Solubility

10 mM in DMSO

Smiles

O=P(O[2H])(O[Li])OP(OP(OC([2H])([2H])[C@@]1([2H])O[C@]([15N]2C([15N]=C([15N]([2H])[2H])[15N]([2H])C3=O)=C3[15N]=C2[2H])([2H])[C@](O[2H])([2H])[C@]1([2H])O[2H])(O[2H])=O)(O[Li])=O

Molecular Formula

C10D14Li2 15N5O14P3

Molecular Weight

554.10

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Abdo A Elfiky, et al. Anti-HCV, nucleotide inhibitors, repurposing against COVID-19. Life Sci. 2020 May 1;248:117477.