Guanosine triphosphate-15N5,d14 (dilithium)
Product Specifications
UNSPSC Description
Guanosine triphosphate-15N5,d14 (GTP-15N5,d14) dilithium is deuterium and 15N labeled Guanosine triphosphate (HY-113225). Guanosine triphosphate is a native nucleotide. The derivatives of GTP may be used as specific inhibitors against COVID-19.
Target Antigen
DNA/RNA Synthesis; Endogenous Metabolite; Isotope-Labeled Compounds; Nucleoside Antimetabolite/Analog; SARS-CoV
Type
Isotope-Labeled Compounds
Related Pathways
Anti-infection;Cell Cycle/DNA Damage;Metabolic Enzyme/Protease;Others
Applications
COVID-19-anti-virus
Field of Research
Cancer; Infection
Solubility
10 mM in DMSO
Smiles
O=P(O[2H])(O[Li])OP(OP(OC([2H])([2H])[C@@]1([2H])O[C@]([15N]2C([15N]=C([15N]([2H])[2H])[15N]([2H])C3=O)=C3[15N]=C2[2H])([2H])[C@](O[2H])([2H])[C@]1([2H])O[2H])(O[2H])=O)(O[Li])=O
Molecular Weight
554.10
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.|[2]Abdo A Elfiky, et al. Anti-HCV, nucleotide inhibitors, repurposing against COVID-19. Life Sci. 2020 May 1;248:117477.
Shipping Conditions
Room temperature
Clinical Information
No Development Reported
Curated Selection
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