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Guanosine triphosphate-13C (dilithium)

Guanosine triphosphate-13C (GTP-13C) dilithium is 13C-labeled Guanosine triphosphate (HY-113225) . Guanosine triphosphate is a native nucleotide. The derivatives of GTP may be used as specific inhibitors against COVID-19.

Product Specifications

Product Name Alternative

GTP-13C (dilithium)

UNSPSC

12352005

Target

DNA/RNA Synthesis; Endogenous Metabolite; Isotope-Labeled Compounds; Nucleoside Antimetabolite/Analog; SARS-CoV

Type

Isotope-Labeled Compounds

Related Pathways

Anti-infection; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Others

Applications

COVID-19-anti-virus

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/guanosine-triphosphate-13c-dilithium.html

Concentration

100 mM in 18.66 μL Tris HCl/H2O buffer pH=7.5

Purity

98.2

Solubility

10 mM in DMSO

Smiles

O[C@@H]1[C@H](O)[C@@H](COP(OP(OP(O)(O[Li])=O)(O[Li])=O)(O)=O)O[C@H]1N2[13CH]=NC3=C2N=C(N)NC3=O

Molecular Formula

C9 13CH14Li2N5O14P3

Molecular Weight

536.04

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Abdo A Elfiky, et al. Anti-HCV, nucleotide inhibitors, repurposing against COVID-19. Life Sci. 2020 May 1;248:117477.

Shipping Conditions

Blue Ice

Storage Conditions

Solution, -20°C, 2 years

Scientific Category

Isotope-Labeled Compounds

Clinical Information

No Development Reported

Curated Selection

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