2-Phosphoglyceric acid

2-Phosphoglyceric acid (DL-2-phosphoglyceric acid) is a glycolytic substrate that is catalyzed by enolase to form phosphoenolpyruvate ester (PEP) . 2-Phosphoglyceric acid inhibits the ferroptosis pathway by down-regulating ACSL4 and up-regulating GPX4, and has significant neuroprotective effects. 2-Phosphoglyceric acid reflects the overall metabolic state and flux of the cell[1][2][3].

Product Specifications

CAS Number

[2553-59-5]

Product Name Alternative

DL-2-phosphoglyceric acid

UNSPSC

12352211

Hazard Statement

H302-H312-H332

Target

Endogenous Metabolite; Ferroptosis; Glutathione Peroxidase; Reactive Oxygen Species (ROS)

Type

Reference compound

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/2-phosphoglyceric-acid.html

Solubility

10 mM in DMSO

Smiles

O=C(O)C(OP(O)(O)=O)CO

Molecular Formula

C3H7O7P

Molecular Weight

186.06

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P501

References & Citations

[1]Ramos A, et al. Relationship between glycolysis and exopolysaccharide biosynthesis in Lactococcus lactis. Appl Environ Microbiol. 2001 Jan;67 (1) :33-41.|[2]Chen H, et al. Metabolomics analysis revealed the neuroprotective role of 2-phosphoglyceric acid in hypoxic-ischemic brain damage through GPX4/ACSL4 axis regulation. Eur J Pharmacol. 2024 May 15;971:176539. |[3]Huang CK, et al. ENO1 and Cancer. Mol Ther Oncolytics. 2022 Jan 3;24:288-298.