Epsilon- (gamma-glutamyl) -lysine

Epsilon- (gamma-glutamyl) -lysine is an N (6) -acyl-L-lysine derivative. The enzyme tissue transglutaminase (tTg) helps the formation of epsilon- (gamma-glutamyl) lysine bonds between ECM components in some disease, such as non-diabetic kidney, glaucoma filtration[1].

Product Specifications

CAS Number

[17105-15-6]

Product Name Alternative

H-Glu (H-Lys-OH) -OH; γ-Glu-ε-Lys

UNSPSC

12352209

Target

Endogenous Metabolite

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/epsilon-gamma-glutamyl-lysine.html

Purity

99.90

Solubility

10 mM in DMSO

Smiles

OC([C@@H](N)CCC(NCCCC[C@H](N)C(O)=O)=O)=O

Molecular Formula

C11H21N3O5

Molecular Weight

275.30

References & Citations

[1]Siegfried G Priglinger, et al. Potential Role of Tissue Transglutaminase in Glaucoma Filtering Surgery. Invest Ophthalmol Vis Sci. 2006 Sep;47 (9) :3835-45.|[2]A M El Nahas, et al. Elevated Epsilon- (Gamma-Glutamyl) lysine in Human Diabetic Nephropathy Results From Increased Expression and Cellular Release of Tissue Transglutaminase.Nephron Clin Pract. 2004;97 (3) :c108-17.