Guanosine 5'-diphosphate-13C10 (dilithium)

Guanosine 5'-diphosphate-13C10 (GDP-13C10) dilithium is 13C-labeled Guanosine 5'-diphosphate (HY-113066) . Guanosine 5'-diphosphate (GDP) is a nucleoside diphosphate that activates adenosine 5'-triphosphate-sensitive K+ channel. Guanosine 5'-diphosphate is a potential iron mobilizer, which prevents the hepcidin-ferroportin interaction and modulates the interleukin-6 (IL-6) /stat-3 pathway. Guanosine 5'-diphosphate can be used in the research of inflammation, such as anemia of inflammation (AI) .

Product Specifications

Product Name Alternative

GDP-13C10 (dilithium)

UNSPSC

12352005

Target

Endogenous Metabolite; Hepcidin; Isotope-Labeled Compounds; Potassium Channel

Type

Isotope-Labeled Compounds

Related Pathways

Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Others

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/guanosine-5-diphosphate-13c10-dilithium.html

Concentration

100 mM in 21.65 μL Tris HCl buffer pH=7.5

Purity

98.7

Solubility

10 mM in DMSO

Smiles

O=P(OP(O[Li])(O[Li])=O)(O)O[13CH][13C@@H]1[13C@@](O)[13C@@](O)[13C@H](N2[13C](N=[13C](N)N[13C]3=O)=[13C]3N=[13CH]2)O1

Molecular Formula

13C10H10Li2N5O11P2

Molecular Weight

461.97

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]S Kajioka, et al. Guanosine diphosphate activates an adenosine 5'-triphosphate-sensitive K+ channel in the rabbit portal vein. J Physiol. 1991 Dec;444:397-418.|[3]Angmo S, et al. Identification of Guanosine 5'-diphosphate as Potential Iron Mobilizer: Preventing the Hepcidin-Ferroportin Interaction and Modulating the Interleukin-6/Stat-3 Pathway. Sci Rep. 2017 Jan 5;7:40097.