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N1-Acetylspermidine-d6 (hydrochloride)

N1-Acetylspermidine-d6 (hydrochloride) is the deuterium labeled N1-Acetylspermidine hydrochloride. N1-Acetylspermidine hydrochloride is an acetyl derivative of polyamine. N1-acetylspermine is the substrate for the polyamine oxidase (PAO) . N1-Acetylspermidine hydrochloride selectively elevates its level in human colorectal adenocarcinomas. N1-acetylspermidine shows cleavage efficiency at apurinic sites in DNA[1][2][3].

Product Specifications

UNSPSC

12352211

Target

Endogenous Metabolite

Type

Isotope-Labeled Compounds

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Cancer

Purity

99.88

Solubility

10 mM in DMSO|H2O : 25mg/mL (ultrasonic)

Smiles

CC(NC([2H])([2H])C([2H])([2H])C([2H])([2H])NCCCCN)=O.Cl.[2]

Molecular Formula

C9H17D6Cl2N3O

Molecular Weight

266.24

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Royo M, et al. Mechanistic studies of mouse polyamine oxidase with N1, N12-bisethylspermine as a substrate. Biochemistry. 2005 May 10;44 (18) :7079-84.|[3]Haukanes BI, et al. Action of spermidine, N1-acetylspermidine, and N8-acetylspermidine at apurinic sites in DNA.|[4]Takenoshita S, et al. Selective elevation of the N1-acetylspermidine level in human colorectal adenocarcinomas. Cancer Res. 1984 Feb;44 (2) :845-7.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light, stored under nitrogen)

Scientific Category

Isotope-Labeled Compounds

Clinical Information

No Development Reported

Frequently Asked Questions

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