2,3-Diphosphoglyceric acid
Product Specifications
UNSPSC Description
2,3-Diphosphoglyceric acid (2,3-DPG) is an intermediate of the glycolytic pathway. 2,3-Diphosphoglyceric acid stabilizes the deoxygenated form of hemoglobin by allosteric binding and facilitates oxygen release at tissue sites. 2, 3-diphosphoglyceric acid has antiparasitic activity. 2,3-Diphosphoglyceric acid can be used in the study of Alzheimer's disease (AD)[1][2][3][4].
Target Antigen
Parasite
Type
Reference compound
Related Pathways
Anti-infection
Applications
Neuroscience-Neurodegeneration
Field of Research
Infection; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/2-3-diphosphoglyceric-acid.html
Solubility
10 mM in DMSO
Smiles
O=C(O)C(OP(O)(O)=O)COP(O)(O)=O
Molecular Weight
266.04
References & Citations
[1]Shakil H. Merchant MD, et al. 24 - Molecular Diagnosis in Hematopathology. Hematopathology (Second Edition).2012, 679-726. |[2]Płoszczyca K, et al. Red Blood Cell 2,3-Diphosphoglycerate Decreases in Response to a 30 km Time Trial Under Hypoxia in Cyclists. Front Physiol. 2021 Jun 15;12:670977. |[3]Morais I, et al. Synthetic Red Blood Cell-Specific Glycolytic Intermediate 2,3-Diphosphoglycerate (2,3-DPG) Inhibits Plasmodium falciparum Development In Vitro. Front Cell Infect Microbiol. 2022 Mar 15;12:840968.|[4]Kosenko EA, et al. Relationship between chronic disturbance of 2,3-diphosphoglycerate metabolism in erythrocytes and Alzheimer disease. CNS Neurol Disord Drug Targets. 2016;15(1):113-23.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-113050/2-3-Diphosphoglyceric-acid-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-113050/
Clinical Information
No Development Reported
CAS Number
138-81-8
Curated Selection
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