2,3-Diphosphoglyceric acid

2,3-Diphosphoglyceric acid (2,3-DPG) is an intermediate of the glycolytic pathway. 2,3-Diphosphoglyceric acid stabilizes the deoxygenated form of hemoglobin by allosteric binding and facilitates oxygen release at tissue sites. 2, 3-diphosphoglyceric acid has antiparasitic activity. 2,3-Diphosphoglyceric acid can be used in the study of Alzheimer's disease (AD) [1][2][3][4].

Product Specifications

CAS Number

[138-81-8]

Product Name Alternative

2,3-DPG

UNSPSC

12352211

Target

Parasite

Type

Reference compound

Related Pathways

Anti-infection

Applications

Neuroscience-Neurodegeneration

Field of Research

Infection; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/2-3-diphosphoglyceric-acid.html

Solubility

10 mM in DMSO

Smiles

O=C(O)C(OP(O)(O)=O)COP(O)(O)=O

Molecular Formula

C3H8O10P2

Molecular Weight

266.04

References & Citations

[1]Shakil H. Merchant MD, et al. 24 - Molecular Diagnosis in Hematopathology. Hematopathology (Second Edition) .2012, 679-726. |[2]Płoszczyca K, et al. Red Blood Cell 2,3-Diphosphoglycerate Decreases in Response to a 30 km Time Trial Under Hypoxia in Cyclists. Front Physiol. 2021 Jun 15;12:670977. |[3]Morais I, et al. Synthetic Red Blood Cell-Specific Glycolytic Intermediate 2,3-Diphosphoglycerate (2,3-DPG) Inhibits Plasmodium falciparum Development In Vitro. Front Cell Infect Microbiol. 2022 Mar 15;12:840968.|[4]Kosenko EA, et al. Relationship between chronic disturbance of 2,3-diphosphoglycerate metabolism in erythrocytes and Alzheimer disease. CNS Neurol Disord Drug Targets. 2016;15 (1) :113-23.