Prostaglandin A2
Prostaglandin A2 (PGA2), a human endogenous metabolite of PGE2, is an antitumor agent. Prostaglandin A2 induces p53-dependent apoptosis. Prostaglandin A2 also has antiviral activity[1][2][3].
Product Specifications
CAS Number
13345-50-1
Product Name Alternative
PGA2; Medullin
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Endogenous Metabolite
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
COVID-19-anti-virus
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/prostaglandin-a2.html
Concentration
29.90 mM * 100 μL in Methyl acetate
Purity
99.0
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
CCCCC[C@H](O)/C=C/[C@@H]1[C@H](C(C=C1)=O)C/C=C\CCCC(O)=O
Molecular Formula
C20H30O4
Molecular Weight
334.45
Precautions
H302, H315, H319, H335
References & Citations
[1]Lee SB, et al. Induction of p53-Dependent Apoptosis by Prostaglandin A2. Biomolecules. 2020 Mar 24;10 (3) :492. |[2]Gorospe M, et al. Protective role of p21 (Waf1/Cip1) against prostaglandin A2-mediated apoptosis of human colorectal carcinoma cells. Mol Cell Biol. 1996 Dec;16 (12) :6654-60. |[3]O'Brien WJ, et al. Assessment of antiviral activity, efficacy, and toxicity of prostaglandin A2 in a rabbit model of herpetic keratitis. Antimicrob Agents Chemother. 1996 Oct;40 (10) :2327-31.
Shipping Conditions
Blue Ice
Storage Conditions
Solution, -20°C, protect from light, 2 years
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
Human Endogenous Metabolite
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