Prostaglandin A2

Prostaglandin A2 (PGA2), a human endogenous metabolite of PGE2, is an antitumor agent. Prostaglandin A2 induces p53-dependent apoptosis. Prostaglandin A2 also has antiviral activity[1][2][3].

Product Specifications

CAS Number

[13345-50-1]

Product Name Alternative

PGA2; Medullin

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Endogenous Metabolite

Type

Reference compound

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Applications

COVID-19-anti-virus

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/prostaglandin-a2.html

Concentration

29.90 mM * 100 μL in Methyl acetate

Purity

99.0

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

CCCCC[C@H](O)/C=C/[C@@H]1[C@H](C(C=C1)=O)C/C=C\CCCC(O)=O

Molecular Formula

C20H30O4

Molecular Weight

334.45

Precautions

H302, H315, H319, H335

References & Citations

[1]Lee SB, et al. Induction of p53-Dependent Apoptosis by Prostaglandin A2. Biomolecules. 2020 Mar 24;10 (3) :492. |[2]Gorospe M, et al. Protective role of p21 (Waf1/Cip1) against prostaglandin A2-mediated apoptosis of human colorectal carcinoma cells. Mol Cell Biol. 1996 Dec;16 (12) :6654-60. |[3]O'Brien WJ, et al. Assessment of antiviral activity, efficacy, and toxicity of prostaglandin A2 in a rabbit model of herpetic keratitis. Antimicrob Agents Chemother. 1996 Oct;40 (10) :2327-31.