α-Hydroxyglutaric acid-13C5 (disodium)

α-Hydroxyglutaric acid-13C5 (sodium) is the 13C labeled α-Hydroxyglutaric acid sodium[1]. α-Hydroxyglutaric acid (2-Hydroxyglutarate) sodium is an α-hydroxy acid form of glutaric acid. α-Hydroxyglutaric acid sodium is a competitive inhibitor of multiple α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases[2].

Product Specifications

CAS Number

[2482467-23-0]

Product Name Alternative

2-Hydroxyglutarate-13C5 (disodium) ; 2-Hydroxyglutaric acid-13C5 (disodium) ; 2-Hydroxypentanedioic acid-13C5 (disodium)

UNSPSC

12352211

Target

Endogenous Metabolite; Histone Demethylase

Type

Isotope-Labeled Compounds

Related Pathways

Epigenetics; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/α-hydroxyglutaric-acid-13c5-disodium.html

Purity

99.80

Solubility

H2O : 125 mg/mL (ultrasonic; warming)

Smiles

O=[13C](O[Na])[13CH2][13CH2][13CH](O)[13C](O[Na])=O

Molecular Formula

13C5H6Na2O5

Molecular Weight

197.04

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Wei Xu, et al. Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases. Cancer Cell. 2011 Jan 18;19 (1) :17-30.