(E/Z) -Farnesyl pyrophosphate
(E/Z) -Farnesyl pyrophosphate ((E/Z) -Farnesyl diphosphate), a 15-carbon isoprenoid, is a metabolic intermediate of the mevalonate (MVA) pathway. (E/Z) -Farnesyl pyrophosphate is a TRPM2 (TRP Channel) agonist, activates TRPM2 opening for ion influx. (E/Z) -Farnesyl pyrophosphate is a key branch substrate for cholesterol synthesis, ubiquinones synthesis, protein farnesylation decoration, and geranyl-geranyl pyrophosphate (GGPP) synthesis[1].
Product Specifications
CAS Number
[13058-04-3]
Product Name Alternative
(E/Z) -Farnesyl diphosphate
UNSPSC
12352211
Hazard Statement
H314
Target
Endogenous Metabolite; TRP Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/farnesyl-pyrophosphate.html
Solubility
10 mM in DMSO
Smiles
O=P(O)(OP(O)(O)=O)OC/C=C(C)/CC/C=C(C)/CC/C=C(C)/C
Molecular Formula
C15H28O7P2
Molecular Weight
382.33
Precautions
P260-P264-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P363-P405-P501
References & Citations
[1]Jing Chen, et al. Farnesyl pyrophosphate is a new danger signal inducing acute cell death. PLoS Biol. 2021 Apr 26;19 (4) :e3001134.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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