MU380
MU380 is a potent and selective CHK1 inhibitor that induces apoptosis and has anticancer activity[1].
Product Specifications
CAS Number
2109805-78-7
UNSPSC
12352005
Hazard Statement
H302
Target
Checkpoint Kinase (Chk)
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mu380.html
Purity
99.6
Solubility
10 mM in DMSO
Smiles
NC1=C(Br)C([C@H]2CNCCC2)=NC3=C(C4=CN(C(F)(F)F)N=C4)C=NN13
Molecular Formula
C15H15BrF3N7
Molecular Weight
430.23
Precautions
H302
References & Citations
[1]Miroslav Boudny, et al. Novel CHK1 inhibitor MU380 exhibits significant single-agent activity in TP53-mutated chronic lymphocytic leukemia cells. Haematologica. 2019 Dec;104 (12) :2443-2455.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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