RTS-V5

RTS-V5 is a dual HDAC/proteasome inhibitor with IC50s of 6.9, 18, 15, 0.27, 0.53 μM for HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, respectively.

Product Specifications

CAS Number

[2285346-31-6]

UNSPSC

12352005

Target

HDAC; Proteasome

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics; Metabolic Enzyme/Protease

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/RTS-V5.html

Solubility

10 mM in DMSO

Smiles

O=C(NO)C1=CC=C(C(N[C@@H](CC(NCC(C)(C)C)=O)C(N[C@@H](C)C(NCC2=CC=CC=C2)=O)=O)=O)C=C1

Molecular Formula

C27H35N5O6

Molecular Weight

525.60

References & Citations

[1]Bhatia S, et al. Discovery of the First-in-Class Dual Histone Deacetylase-Proteasome Inhibitor. J Med Chem. 2018 Nov 21;61 (22) :10299-10309.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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