RTS-V5
RTS-V5 is a dual HDAC/proteasome inhibitor with IC50s of 6.9, 18, 15, 0.27, 0.53 μM for HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, respectively.
Product Specifications
CAS Number
2285346-31-6
UNSPSC
12352005
Target
HDAC; Proteasome
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/RTS-V5.html
Solubility
10 mM in DMSO
Smiles
O=C(NO)C1=CC=C(C(N[C@@H](CC(NCC(C)(C)C)=O)C(N[C@@H](C)C(NCC2=CC=CC=C2)=O)=O)=O)C=C1
Molecular Formula
C27H35N5O6
Molecular Weight
525.60
References & Citations
[1]Bhatia S, et al. Discovery of the First-in-Class Dual Histone Deacetylase-Proteasome Inhibitor. J Med Chem. 2018 Nov 21;61 (22) :10299-10309.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
TA800365S 30 µL
ARL2BP Mouse Monoclonal Antibody [Clone ID: OTI1G10]
Sign In for Pricing
View Details