RTS-V5
RTS-V5 is a dual HDAC/proteasome inhibitor with IC50s of 6.9, 18, 15, 0.27, 0.53 μM for HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, respectively.
Product Specifications
CAS Number
[2285346-31-6]
UNSPSC
12352005
Target
HDAC; Proteasome
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/RTS-V5.html
Solubility
10 mM in DMSO
Smiles
O=C(NO)C1=CC=C(C(N[C@@H](CC(NCC(C)(C)C)=O)C(N[C@@H](C)C(NCC2=CC=CC=C2)=O)=O)=O)C=C1
Molecular Formula
C27H35N5O6
Molecular Weight
525.60
References & Citations
[1]Bhatia S, et al. Discovery of the First-in-Class Dual Histone Deacetylase-Proteasome Inhibitor. J Med Chem. 2018 Nov 21;61 (22) :10299-10309.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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