DC1

DC1, an analogue of the minor groove-binding DNA alkylator CC-1065, is a ADC Cytotoxin. DC1 can be used in synthesis of antibody-drug conjugates for the targeted treatment of cancer.

Product Specifications

CAS Number

[169901-27-3]

UNSPSC

12352203

Target

ADC Payload; DNA Alkylator/Crosslinker

Type

ADC Related

Related Pathways

Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/DC1.html

Solubility

10 mM in DMSO

Smiles

O=C(C(N1)=CC2=C1C=CC(NC(CCS)=O)=C2)NC3=CC4=C(NC(C(N5C[C@@H](CCl)C6=C5C=C(O)C7=CC=CC=C67)=O)=C4)C=C3

Molecular Formula

C34H28ClN5O4S

Molecular Weight

638.14

References & Citations

[1]Kovtun YV, et al. Antibody-drug conjugates designed to eradicate tumors with homogeneous and heterogeneous expression of the target antigen. Cancer Res. 2006 Mar 15;66 (6) :3214-21.