TGFβRI-IN-6
TGFβRI-IN-6 (compound 22) is a potent TGFβRI inhibitor with an IC50 value of 0.55 nM. TGFβRI-IN-6 has the potential to enhance anti-tumor immunity[1].
Product Specifications
CAS Number
2072051-04-6
UNSPSC
12352005
Target
TGF-β Receptor
Type
Reference compound
Related Pathways
TGF-beta/Smad
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/tgfβri-in-6.html
Solubility
10 mM in DMSO
Smiles
FC1=CN=CC=C1NC2=C(C=CN3)C3=NC(C4=NC(C(F)(F)F)=CC=C4)=N2
Molecular Formula
C17H10F4N6
Molecular Weight
374.30
References & Citations
[1]Harikrishnan LS, et, al. Heterobicyclic inhibitors of transforming growth factor beta receptor I (TGFβRI) . Bioorg Med Chem. 2018 Mar 1;26 (5) :1026-1034.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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