VU6001376
VU6001376 is a potent and selective positive allosteric modulator of the metabotropic glutamate receptor 4 (mGlu4 PAM) with an EC50 of 50.1 nM[1].
Product Specifications
CAS Number
1968546-34-0
UNSPSC
12352005
Target
MGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/vu6001376.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1CC(F)(F)C1)C2=NSC3=CC(NC4=NNC5=C4N=CC=C5)=CC=C32
Molecular Formula
C18H14F2N6OS
Molecular Weight
400.41
References & Citations
[1]Bollinger SR, et al. Discovery, Structure-Activity Relationship, and Biological Characterization of a Novel Series of 6- ((1 H-Pyrazolo[4,3- b]pyridin-3-yl) amino) -benzo[ d]isothiazole-3-carboxamides as Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 4 (mGlu4) . J Med Chem. 2019 Jan 10;62 (1) :342-358.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MGluR4
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