PROTAC CDK9 degrader-2
PROTAC CDK9 degrader-2 (compound 11c) is a potent and selective CDK9 degrader based on PROTAC, with an IC50 of 17 μM in MCF-7 cell lines. Natural product Wogonin (CDK ligand) binds ubiquitin E3 ligase Cereblon (CRBN) via a linker to form PROTAC[1].
Product Specifications
CAS Number
[2435721-30-3]
UNSPSC
12352005
Target
CDK; PROTACs
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; PROTAC
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cdk9-antagonist-1.html
Purity
99.22
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C=C(C1=CC=CC=C1)O2)C3=C2C(OCC4=CN(CCCCCCCC(NC5=C(C(N(C6C(NC(CC6)=O)=O)C7=O)=O)C7=CC=C5)=O)N=N4)=C(O)C=C3O
Molecular Formula
C39H36N6O10
Molecular Weight
748.74
References & Citations
[1]Bian J , et al. Discovery of Wogonin-based PROTACs against CDK9 and capable of achieving antitumor activity. Bioorg Chem. 2018 Dec;81:373-381.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK9
Available Sizes
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