SGLT inhibitor-1
SGLT inhibitor-1 is a potent dual inhibitor of sodium glucose co-transporter proteins (SGLTs), inhibits hSGLT1 and hSGLT2 with IC50s of 43 nM and 9 nM, respectively[1].
Product Specifications
CAS Number
2247314-23-2
UNSPSC
12352005
Target
SGLT
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/sglt-inhibitor-1.html
Solubility
10 mM in DMSO
Smiles
OC[C@@H]1[C@@H](F)[C@H](O)[C@@H](O)[C@H](C2=CC(CC3=CC(OCCO4)=C4C=C3)=C(OCC5)C5=C2OC)O1
Molecular Formula
C24H27FO8
Molecular Weight
462.46
References & Citations
[1]Xu G, et al. Design, synthesis and biological evaluation of (2S,3R,4R,5S,6R) -5-fluoro-6- (hydroxymethyl) -2-aryltetrahydro-2H-pyran-3,4-diols as potent and orally active SGLT dual inhibitors. Bioorg Med Chem Lett. 2018 Nov 15;28 (21) :3446-3453.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
SGLT1; SGLT2
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