CP-195543

CP-195543 is a potent, selective and orally active leukotriene B4 (LTB4) receptor antagonist with IC50s of 6.8, 37.0 nM for human neutrophils and murine spleen membranes, respectively. CP-195543 blocks CD11b up-regulation. CP-195543 inhibits LTB4-mediated neutrophil infiltration[1].

Product Specifications

CAS Number

[204981-48-6]

UNSPSC

12352005

Target

Leukotriene Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/cp-195543.html

Solubility

10 mM in DMSO

Smiles

O=C(O)C1=CC=C(C(F)(F)F)C=C1C2=CC=C3[C@H](O)[C@@H](CC4=CC=CC=C4)COC3=C2

Molecular Formula

C24H19F3O4

Molecular Weight

428.40

References & Citations

[1]Showell HJ, et al. The preclinical pharmacological profile of the potent and selective leukotriene B4 antagonist CP-195543. J Pharmacol Exp Ther. 1998 Jun;285 (3) :946-54.