PDE5-IN-2
Product Specifications
UNSPSC Description
PDE5-IN-2 is a potent, highly selective, and orally active PDE5 inhibitor, with an IC50 of 0.31 nM, less potently inhibits PDE2A, PDE10A, PDE4D2, and PDE6C, with IC50s of 106, 46, 43, 1.2 nM, respectively. Anti-pulmonary arterial hypertension activity[1].
Target Antigen
Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/PDE5-IN-2.html
Solubility
10 mM in DMSO
Smiles
O=C1C2=C(C3=NC=CS3)NC(CC4=CC(OCO5)=C5C=C4)=C2OC6=CC(NCCOC)=CC(O)=C61
Molecular Weight
491.52
References & Citations
[1]Wu D, et al. Optimization of Chromeno[2,3- c]pyrrol-9(2 H)-ones as Highly Potent, Selective, and Orally Bioavailable PDE5 Inhibitors: Structure-Activity Relationship, X-ray Crystal Structure, and Pharmacodynamic Effect on Pulmonary Arterial Hypertension. J Med Chem. 2018 Sep 27;61(18):8468-8473.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-112704/PDE5-IN-2-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-112704/
Clinical Information
No Development Reported
CAS Number
2244517-61-9
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
![MelanA (MLANA) Mouse Monoclonal Antibody (HRP conjugated) [Clone ID: OTI2D6]](https://cdn.genprice.uk/genprice/genprice2.png)
TA807175BM 100 µL
MelanA (MLANA) Mouse Monoclonal Antibody (HRP conjugated) [Clone ID: OTI2D6]
Ask
View Details 
MBS6203843-01 0.1 mL
Trefoil Factor 2 (TFF2, SML1, Spasmolysin, Spasmolytic Polypeptide, SP) (MaxLight 490)
Ask
View Details MBS6203843-02 5x 0.1 mL
Trefoil Factor 2 (TFF2, SML1, Spasmolysin, Spasmolytic Polypeptide, SP) (MaxLight 490)
Ask
View Details