ATM Inhibitor-1
ATM Inhibitor-1 is a highly potent, selective and orally active ATM inhibitor, with an IC50 of 0.7 nM, shows weak activity against mTOR (IC50, 21 μM), DNAPK (IC50, 2.8 μM), PI3Kα (IC50, 3.8 μM), PI3Kβ (IC50, 10.3 μM), PI3Kγ (IC50, 3 μM) and PI3Kδ (IC50, 0.73 μM) . ATM Inhibitor-1 exhibits anti-tumor activity[1].
Product Specifications
CAS Number
2135639-94-8
UNSPSC
12352005
Target
ATM/ATR
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ATM_Inhibitor-1.html
Solubility
10 mM in DMSO
Smiles
C[C@@H](C1CCOCC1)NC2=C(C(NC)=O)N=NC3=CC=C(C4=CC=C(OCCCN(C)C)N=C4)C=C32
Molecular Formula
C27H36N6O3
Molecular Weight
492.61
References & Citations
[1]Barlaam B, et al. Discovery of a Series of 3-Cinnoline Carboxamides as Orally Bioavailable, Highly Potent, and Selective ATM Inhibitors. CS Med Chem Lett. 2018 Jul 13;9 (8) :809-814.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ATM
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
MBS713383-01 0.1 mL
Rabbit anti-human fibroblast growth factor 13 polyclonal Antibody
Sign In for Pricing
View Details MBS713383-02 5x 0.1 mL
Rabbit anti-human fibroblast growth factor 13 polyclonal Antibody
Sign In for Pricing
View Details 
MBS6433954-01 0.1 mL
PTGIR (Prostaglandin I2 Receptor, IP, PRIPR) (AP)
Sign In for Pricing
View Details MBS6433954-02 5x 0.1 mL
PTGIR (Prostaglandin I2 Receptor, IP, PRIPR) (AP)
Sign In for Pricing
View Details