SPLA2-X Inhibitor 31

SPLA2-X Inhibitor 31 is a selective secreted phospholipase A2 type X (sPLA2-X) inhibitor with IC50s of 26 nM, 310 nM, and 2230 nM for sPLA2-X, sPLA2-IIa, and sPLA2-V, respectively[1].

Product Specifications

CAS Number

[2241025-50-1]

UNSPSC

12352005

Target

Phospholipase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/sPLA2-X_Inhibitor_31.html

Solubility

10 mM in DMSO

Smiles

FC(F)(F)OC1=CC=C(C=C(C(N)=O)N2C3=CC(CCC(O)=O)=CC=C3)C2=C1

Molecular Formula

C19H15F3N2O4

Molecular Weight

392.33

References & Citations

[1]Knerr L, et al. Discovery of a Series of Indole-2 Carboxamides as Selective Secreted Phospholipase A2 Type X (sPLA2-X) Inhibitors. ACS Med Chem Lett. 2018 Jun 23;9 (7) :594-599.