SPLA2-X Inhibitor 31
SPLA2-X Inhibitor 31 is a selective secreted phospholipase A2 type X (sPLA2-X) inhibitor with IC50s of 26 nM, 310 nM, and 2230 nM for sPLA2-X, sPLA2-IIa, and sPLA2-V, respectively[1].
Product Specifications
CAS Number
[2241025-50-1]
UNSPSC
12352005
Target
Phospholipase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/sPLA2-X_Inhibitor_31.html
Solubility
10 mM in DMSO
Smiles
FC(F)(F)OC1=CC=C(C=C(C(N)=O)N2C3=CC(CCC(O)=O)=CC=C3)C2=C1
Molecular Formula
C19H15F3N2O4
Molecular Weight
392.33
References & Citations
[1]Knerr L, et al. Discovery of a Series of Indole-2 Carboxamides as Selective Secreted Phospholipase A2 Type X (sPLA2-X) Inhibitors. ACS Med Chem Lett. 2018 Jun 23;9 (7) :594-599.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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