MK-8318

MK-8318 is a potent and selective CRTh2 receptor antagonist with a Ki of 5.0 nM.

Product Specifications

CAS Number

[1416581-40-2]

UNSPSC

12352005

Target

Prostaglandin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Inflammation/Immunology; Endocrinology

Assay Protocol

https://www.medchemexpress.com/MK-8318.html

Solubility

10 mM in DMSO

Smiles

FC1=CC=C(N(C(C2=CC=C(OC(F)(F)F)C=C2)=O)[C@@H](CCC3)[C@@H]3[C@H]4N(C(CCC(O)=O)=O)C5CC5)C4=C1

Molecular Formula

C27H26F4N2O5

Molecular Weight

534.50

References & Citations

[1]Huang X, et al. Discovery of MK-8318, a Potent and Selective CRTh2 Receptor Antagonist for the Treatment of Asthma. ACS Med Chem Lett. 2018 Jun 23;9 (7) :679-684.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Curated Selection

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