MK-8318
MK-8318 is a potent and selective CRTh2 receptor antagonist with a Ki of 5.0 nM.
Product Specifications
CAS Number
[1416581-40-2]
UNSPSC
12352005
Target
Prostaglandin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Inflammation/Immunology; Endocrinology
Assay Protocol
https://www.medchemexpress.com/MK-8318.html
Solubility
10 mM in DMSO
Smiles
FC1=CC=C(N(C(C2=CC=C(OC(F)(F)F)C=C2)=O)[C@@H](CCC3)[C@@H]3[C@H]4N(C(CCC(O)=O)=O)C5CC5)C4=C1
Molecular Formula
C27H26F4N2O5
Molecular Weight
534.50
References & Citations
[1]Huang X, et al. Discovery of MK-8318, a Potent and Selective CRTh2 Receptor Antagonist for the Treatment of Asthma. ACS Med Chem Lett. 2018 Jun 23;9 (7) :679-684.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
DP
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