N1-Methylpseudouridine-5′-triphosphate
N1-Methylpseudouridine-5′-triphosphate (1-Methylpseudouridine-5′-triphosphate) is a nucleobase-modified nucleotide, used for synthesizing mRNA with reduced immunogenicity and improved stability.
Product Specifications
CAS Number
[1428903-59-6]
Product Name Alternative
1-Methylpseudouridine-5′-triphosphate
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
DNA/RNA Synthesis; Nucleoside Antimetabolite/Analog
Type
Oligonucleotides
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/n1-methylpseudouridine-5-triphosphate.html
Concentration
100 mM * 1 mL in water
Purity
99.88
Solubility
10 mM in H2O
Smiles
O[C@H]1[C@@H](O)[C@H](C(C(N2)=O)=CN(C)C2=O)O[C@@H]1COP(OP(OP(O)(O)=O)(O)=O)(O)=O
Molecular Formula
C10H17N2O15P3
Molecular Weight
498.17
Precautions
H302, H315, H319
References & Citations
[1]Andries O, Mc Cafferty S, De Smedt SC, Weiss R, Sanders NN, Kitada T. N (1) -methylpseudouridine-incorporated mRNA outperforms pseudouridine-incorporated mRNA by providing enhanced protein expression and reduced immunogenicity in mammalian cell lines and mice. J Control Release. 2015;217:337-344.
Shipping Conditions
Blue Ice
Storage Conditions
Solution, -20°C, 2 years
Scientific Category
Oligonucleotides
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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