HZ52

HZ52 is a potent, reversible 5-lipoxygenase inhibitor, blocking leukotriene synthesis with an IC50 of 0.7 μM in intact human polymorphonuclear leukocytes[1].

Product Specifications

CAS Number

1077626-51-7

UNSPSC

12352005

Target

Lipoxygenase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/hz52.html

Solubility

10 mM in DMSO

Smiles

ClC1=CC(NC2=CC=C(C=C2)C3=CC=CC=C3)=NC(SC(C(O)=O)CCCCCC)=N1

Molecular Formula

C24H26ClN3O2S

Molecular Weight

456.00

References & Citations

[1]Greiner C, et al. 2- (4- (Biphenyl-4-ylamino) -6-chloropyrimidin-2-ylthio) octanoic acid (HZ52) --a novel type of 5-lipoxygenase inhibitor with favourable molecular pharmacology and efficacy in vivo. Br J Pharmacol. 2011 Sep;164 (2b) :781-93.