CRT5
CRT5, a pyrazine benzamide, is a potent and selective inhibitor for all three isoforms of PKD in endothelial cells treated with VEGF (IC50s = 1, 2, and 1.5 nM for PKD1, PKD2, and PKD3, respectively) . CRT5 decreases VEGF-induced endothelial migration, proliferation and tubulogenesis[1].
Product Specifications
CAS Number
1034297-58-9
Product Name Alternative
CRT0066051
UNSPSC
12352005
Target
PKD
Type
Reference compound
Related Pathways
Apoptosis
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/crt5.html
Purity
98.70
Solubility
10 mM in DMSO
Smiles
O=C(NCCN(C)C)C1=CC=CC(C2=CC(C3=CC=C4C=C(OCC)C=CC4=C3)=C(N)N=C2)=C1
Molecular Formula
C28H30N4O2
Molecular Weight
454.56
References & Citations
[1]Evans IM, et al. Characterization of the biological effects of a novel protein kinase D inhibitor in endothelial cells. Biochem J. 2010 Aug 1;429 (3) :565-72.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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