Acetoacetic acid

Acetoacetic acid is an oxidative stress inducer that affects the antioxidant enzyme system and lipoprotein metabolism. Acetoacetic acid induces oxidative stress by decreasing the mRNA expression and activity of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px), increasing MDA content, and inhibiting very low density lipoprotein (VLDL) assembly by downregulating apolipoprotein ApoB100, ApoE, and low density lipoprotein receptor (LDLR), leading to triglyceride (TG) accumulation in hepatocytes. Acetoacetic acid can be used to study metabolic diseases[1][2][3].

Product Specifications

CAS Number

[541-50-4]

UNSPSC

12352211

Hazard Statement

H315, H318, H335

Target

Endogenous Metabolite

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/3-Oxobutanoic_acid.html

Purity

95.0

Solubility

H2O : 50 mg/mL (ultrasonic)

Smiles

CC(CC(O)=O)=O

Molecular Formula

C4H6O3

Molecular Weight

102.09

Precautions

H315, H318, H335

References & Citations

[1]Shi X, et al. Acetoacetic acid induces oxidative stress to inhibit the assembly of very low density lipoprotein in bovine hepatocytes. J Dairy Res. 2016 Nov;83 (4) :442-446.