HS80

HS-80 is an enantiomer of Fasnall, which is a selective fatty acid synthase (FASN) inhibitor. HS-80 is able to inhibit the incorporation of tritiated acetate into lipids with an IC50 of 7.13 μM.

Product Specifications

CAS Number

[2138838-57-8]

UNSPSC

12352005

Target

Fatty Acid Synthase (FASN)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/HS80.html

Solubility

10 mM in DMSO

Smiles

CC1=C(C)SC2=NC=NC(N[C@H]3CCN(CC4=CC=CC=C4)C3)=C21

Molecular Formula

C19H22N4S

Molecular Weight

338.47

References & Citations

[1]Alwarawrah Y, et al. Fasnall, a Selective FASN Inhibitor, Shows Potent Anti-tumor Activity in the MMTV-Neu Model of HER2 (+) Breast Cancer. Cell Chem Biol. 2016 Jun 23;23 (6) :678-88.