Menaquinone-7-13C6

Menaquinone-7-13C6 is the 13C-labeled Menaquinone-7. Menaquinone-7 (Vitamin K2-7), belongs to a class of K2-vitamin homologs, is originally discovered as the anti-hemorrhagic factors[1]. Menaquinone-7 (Vitamin K2-7) is identified as the most bioactive cofactor for the carboxylation reaction of Gla-proteins [2]. Supplementation with Menaquinone-7 (Vitamin K2-7) is a pharmacological option for activating matrix Gla protein and intervening in the progression of calcific aortic valve stenosis (CAVS) [3].

Product Specifications

Product Name Alternative

Vitamin K2-7-13C6; Vitamin K2 (35) -13C6; Vitamin MK-7-13C6

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

Others

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/menaquinone-7-13c6.html

Purity

96.0

Solubility

Ethanol : 10 mg/mL (ultrasonic; warming)

Smiles

O=C1C(C/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)\C)=C(C)C([13C]2=[13C]1[13CH]=[13CH][13CH]=[13CH]2)=O

Molecular Formula

C40 13C6H64O2

Molecular Weight

654.96

Precautions

H302, H315, H319, H335

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Thijssen, H H., et al., 1994. Vitamin K distribution in rat tissues: dietary phylloquinone is a source of tissue menaquinone-4. The British journal of nutrition. 72 (3) : 415-25.|[3]Conly, J M., et al., 1994. The contribution of vitamin K2 (menaquinones) produced by the intestinal microflora to human nutritional requirements for vitamin K. The American journal of gastroenterology. 89 (6) : 915-23.|[4]Peeters FECM, et al. Bicuspid Aortic Valve Stenosis and the Effect of Vitamin K2 on Calcification Using 18F-Sodium Fluoride Positron Emission Tomography/Magnetic Resonance: The BASIK2 Rationale and Trial Design. Nutrients. 2018 Mar 21;10 (4) . pii: E386.