ABT-702 (hydrochloride)

ABT-702 (hydrochloride) is a potent, orally active, and selective adenosine kinase (AK) inhibitor with an IC50 of 1.7 nM. ABT-702 (hydrochloride) shows >1300-fold selectivity for AK over other biological targets, including cyclooxygenases-1 and -2. ABT-702 (hydrochloride) attenuates inflammation in diabetic retinopathy by increasing free adenosine levels. ABT-702 (hydrochloride) shows analgesic and anti-inflammatory effects in vivo. ABT-702 (hydrochloride) can be used for diabetic retinopathy research[1][2][3].

Product Specifications

CAS Number

[2624336-92-9]

Product Name Alternative

Adenosine Kinase Inhibitor (hydrochloride)

UNSPSC

12352005

Target

Adenosine Kinase; Adenosine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/abt-702-hydrochloride.html

Purity

98.29

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

NC1=C(C(C2=CC=CC(Br)=C2)=CC(C3=CC=C(N4CCOCC4)N=C3)=N5)C5=NC=N1.Cl

Molecular Formula

C22H20BrClN6O

Molecular Weight

499.79

References & Citations

[1]Jarvis MF, et al. ABT-702 (4-amino-5- (3-bromophenyl) -7- (6-morpholinopyridin-3-yl) pyrido[2, 3-d]pyrimidine), a novel orally effective adenosine kinase inhibitor with analgesic and anti-inflammatory properties: I. In vitro characterization and acute antinociceptive effects in the mouse. J Pharmacol Exp Ther. 2000 Dec;295 (3) :1156-64.|[2]Parkinson FE, et al. The Effect of Endogenous Adenosine on Neuronal Activity in Rats: An FDG PET Study. J Neuroimaging. 2016 Jul;26 (4) :403-5.|[3]Elsherbiny NM, et al. ABT-702, an adenosine kinase inhibitor, attenuates inflammation in diabetic retinopathy. Life Sci. 2013 Jul 30;93 (2-3) :78-88.