Chk2-IN-1
Chk2-IN-1 (compound 1) is a potent and selective inhibitor of checkpoint kinase 2 (Chk2), with IC50s of 13.5 nM and 220.4 nM for Chk2 and Chk1, respectively. Chk2-IN-1 can elicit a strong ataxia telangiectasia mutated (ATM) -dependent Chk2-mediated radioprotection effect[1].
Product Specifications
CAS Number
[724708-21-8]
Product Name Alternative
Hymenialdisine analogue-1
UNSPSC
12352005
Target
Checkpoint Kinase (Chk) ; Choline Kinase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Neuronal Signaling
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/chk2-in-1.html
Solubility
10 mM in DMSO
Smiles
O=C(C(N1)=C/2C3=C1C=CC=C3)NCCC2=C4N=C(N)NC\4=O
Molecular Formula
C15H13N5O2
Molecular Weight
295.30
References & Citations
[1]Nguyen TNT, et, al. Radioprotection by hymenialdisine-derived checkpoint kinase 2 inhibitors. ACS Chem Biol. 2012 Jan 20;7 (1) :172-84.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Chk1; Chk2; CHKα
Available Sizes
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