Flt-3 Inhibitor III
Flt-3 Inhibitor III is a potent and selective FLT3 kinase inhibitor with an 50 of 50 nM. Flt-3 Inhibitor III shows less active against other kinases. Flt-3 Inhibitor III has anticancer effects[1].
Product Specifications
CAS Number
852045-46-6
UNSPSC
12352005
Target
FLT3; Tie
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/flt-3-inhibitor-iii.html
Solubility
10 mM in DMSO
Smiles
C1(NC2=CC=C(OCCN3CCCC3)C=C2)=NC=C(C4=CC=CC=C4)S1
Molecular Formula
C21H23N3OS
Molecular Weight
365.49
References & Citations
[1]Pascal Furet, et al. Aromatic interactions with phenylalanine 691 and cysteine 828: a concept for FMS-like tyrosine kinase-3 inhibition. Application to the discovery of a new class of potential antileukemia agents. J Med Chem. 2006 Jul 27;49 (15) :4451-4.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Tie2
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