STAT3-IN-5

STAT3-IN-5 is a potent STAT3 inhibitor. STAT3-IN-5 inhibits STAT3-Y705 phosphorylation with an EC50 value of 170 nM. STAT3-IN-5 inhibits cytokine induced JAK activation. STAT3-IN-5 induces apoptosis. STAT3-IN-5 can be used in research of cancer[1].

Product Specifications

CAS Number

[1041438-68-9]

UNSPSC

12352005

Target

STAT

Type

Reference compound

Related Pathways

JAK/STAT Signaling; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/stat3-in-5.html

Solubility

10 mM in DMSO

Smiles

N#CC1=C(C(F)=C(N2C=C(C(C3=CC(F)=C(C(F)=C32)F)=O)C(OCC)=O)C(F)=C1F)F

Molecular Formula

C19H7F7N2O3

Molecular Weight

444.26

References & Citations

[1]Xu J, et, al. Inhibition of the signal transducer and activator of transcription-3 (STAT3) signaling pathway by 4-oxo-1-phenyl-1,4-dihydroquinoline-3-carboxylic acid esters. J Med Chem. 2008 Jul 24;51 (14) :4115-21.